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Full name: Interleukin-2
Aliases: TCGF and lymphokine1
Size: 15.5–16.0 kDa2,3
Family: IL-2 family (IL-2, IL-4, IL-7, IL-9, IL-15, and IL-21)3
Receptors: IL-2 receptor3
Major cellular sources: Activated CD4+ and CD8+ T cells, naïve T cells, NK cells, NKT cells, DCs, and mast cells2-4
Major cellular targets: CD4+ and CD8+ T cells, B cells, NK cells, and ILCs3
Disease states associated with: Immune diseases, inflammation, autoimmune diseases, inflammatory bowel disease, and allograft rejection2,5
Major physiologic functions:
CD: cluster of differentiation; DC: dendritic cell; IL: interleukin; ILC: innate lymphoid cell; NK: natural killer; NKT: natural killer T; TCGF: T-cell growth factor; Tfh: T follicular helper; Th: T helper; Treg: regulatory T.
Adverse events should be reported. Reporting forms and information can be found for the UK at www.mhra.gov.uk/yellowcard or search for MHRA Yellow Card in the Google Play or Apple App Store, or for Ireland at https://www.hpra.ie/homepage/about-us/report-an-issue. Adverse events and product complaints should also be reported to Amgen Limited on +44 (0)1223 436441 (UK and Northern Ireland) or Freephone 1800 535 160 (Ireland)