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Full name: Cytotoxic T-lymphocyte associated protein 4
Aliases: CD152, GSE, GRD4, ALPS5, CD152, IDDM12, and CELIAC31,2
Family: Immunoglobulin superfamily1
Receptors: CTLA-42
Major cellular sources: CD4+ and CD8+ T cells and Treg cells2
Major cellular targets: T cells2,3
Disease states associated with: Autoimmune diseases and T-cell–mediated diseases5
Major physiologic functions:
ALPS5: autoimmune lymphoproliferative syndrome, type V; APC: antigen-presenting cell; CD: cluster of differentiation; CELIAC3: celiac disease 3; DC: dendritic cell; GRD4: Ground-like domain-containing protein IDDM12: insulin-dependent diabetes mellitus 12; TCR: T-cell receptor; Treg: regulatory T.
Adverse events should be reported. Reporting forms and information can be found for the UK at www.mhra.gov.uk/yellowcard or search for MHRA Yellow Card in the Google Play or Apple App Store, or for Ireland at https://www.hpra.ie/homepage/about-us/report-an-issue. Adverse events and product complaints should also be reported to Amgen Limited on +44 (0)1223 436441 (UK and Northern Ireland) or Freephone 1800 535 160 (Ireland)