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Full name: B-cell activating factor
Aliases: TALL-1, THANK, BlyS, zTNF-4, and TNFSF-13b1-3
Size: 17 kDa3
Family: TNF ligand family1
Receptors: BAFF-R, TACI, and BCMA2,4
Major cellular sources: Monocytes, macrophages, DC, bone marrow stromal cells, and T cells2,4
Major cellular targets: B cells3,
Disease states associated with: Autoimmune rheumatic diseases, particularly systemic lupus erythematosus and Sjögren’s syndrome2
Major physiologic functions:
BAFF-R: BAFF receptor; BCMA: B-cell maturation antigen; BLyS: B-lymphocyte stimulator; DC: dendritic cell; NF-KB: nuclear factor kappa B; TACI: transmembrane activator and calcium-modulating cyclophilin ligand interactor; TALL-1: apoptosis ligand-related leukocyte-expressed ligand 1; THANK: TNF homolog that activates apoptosis, NF-κB, and c-Jun NH2-terminal kinase; TNF: tumor necrosis factor; TNFSF: TNF ligand superfamily.
Adverse events should be reported. Reporting forms and information can be found for the UK at www.mhra.gov.uk/yellowcard or search for MHRA Yellow Card in the Google Play or Apple App Store, or for Ireland at https://www.hpra.ie/homepage/about-us/report-an-issue. Adverse events and product complaints should also be reported to Amgen Limited on +44 (0)1223 436441 (UK and Northern Ireland) or Freephone 1800 535 160 (Ireland)