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Full name: Interferon gamma
Aliases: IFG, IFI, and IMD691
Size: 40–60 kDa2
Family: Only member of the type II IFN class1,3
Receptors: IFNGR1/IFNGR22,3
Major cellular sources: NK cells, NKT cells, macrophages, myelomonocytic cells, Th1 cells, cytotoxic T lymphocytes, and B cells2
Major cellular targets: Epithelial cells, macrophages, DCs, NK cells, T cells, and B cells2
Disease states associated with: Rheumatoid arthritis, atopic dermatitis, and pathogenic infections2
Major physiologic functions:
IFG: interferon gamma; IFN: interferon; IFNGR: IFN-γ receptor; IL: interleukin; JAK: Janus kinase; MHC: major histocompatibility complex; NK: natural killer; NKT: natural killer T; STAT: signal transducer and activator of transcription; Th: T helper; DCs: dendritic cells
Adverse events should be reported. Reporting forms and information can be found for the UK at www.mhra.gov.uk/yellowcard or search for MHRA Yellow Card in the Google Play or Apple App Store, or for Ireland at https://www.hpra.ie/homepage/about-us/report-an-issue. Adverse events and product complaints should also be reported to Amgen Limited on +44 (0)1223 436441 (UK and Northern Ireland) or Freephone 1800 535 160 (Ireland)