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Full name: Phosphodiesterase 4
Size: 50–125 kDa1
Family: PDE4 isoenzyme subfamily (PDE4A to PDE4D) of the phosphodiesterase enzyme family2
Major cellular sources: Neutrophils, T cells, macrophages, monocytes, eosinophils, DCs, NK cells, epithelial cells, keratinocytes, chondrocytes, and synoviocytes2,3
Major cellular targets: Epithelial cells, such as those lining the airways3
Disease states associated with: Asthma, chronic obstructive pulmonary disease, psoriasis, psoriatic arthritis, and Behçet’s disease2,4
Major physiologic functions:
AMP: adenosine monophosphate; cAMP: cyclic AMP; DC: dendritic cell; IFN-γ: interferon gamma; IL: interleukin; NK: natural killer; TNF: tumor necrosis factor.
Adverse events should be reported. Reporting forms and information can be found for the UK at www.mhra.gov.uk/yellowcard or search for MHRA Yellow Card in the Google Play or Apple App Store, or for Ireland at https://www.hpra.ie/homepage/about-us/report-an-issue. Adverse events and product complaints should also be reported to Amgen Limited on +44 (0)1223 436441 (UK and Northern Ireland) or Freephone 1800 535 160 (Ireland)